Dr. Jun Kameoka, an associate professor in the Department of Electrical and Computer Engineering at Texas A&M University, and several co-authors recently had their paper published in the prestigious research publication, Science Signaling.
The paper titled "mMAPS: A Flow-Proteometric Technique to Analyze Protein-Protein Interactions in Individual Signaling Complexes" can be found at http://stke.sciencemag.org/cgi/content/abstract/7/315/rs1.
In his paper Kameoka says signal transduction is a dynamic process that regulates cellular functions through multiple types of biomolecular interactions, such as the interactions between proteins and between proteins and nucleic acids. However, the techniques currently available for identifying protein-protein or protein–nucleic acid complexes typically provide information about the overall population of signaling complexes in a sample instead of information about the individual signaling complexes therein.
His team developed a technique called "microchannel for multiparameter analysis of proteins in a single complex" (mMAPS) that simultaneously detected individual target proteins either single or in a multicomponent complex in cell or tissue lysates. They expect that this technique may reveal new aspects of molecular interaction dynamics for cancer research.
Kameoka received his Ph.D. in electrical engineering from Cornell University in 2002. After working as a postdoctoral associate at Cornell, he joined the electrical engineering department at Texas A&M as an assistant professor in 2004.
Kameoka has been working on a number of projects including research on nano and microfluidics, nanosensors and Molecular Manipulation, bio-micromachining and BioMEMS. He is the author of numerous publications and has received several patents.
Science Signaling is the premier journal of cell signaling in physiology and disease.