• Assistant Professor
Daniel Alge

Educational Background

  • Postdoctoral, University of Colorado Boulder
  • Ph.D., Biomedical Engineering, Purdue University
  • B.S., Biosystems Engineering, Clemson University

Research Interests

  • Dr. Daniel L. Alge is assistant professor in the Department of Biomedical Engineering at Texas A&M University. His research is in biomaterials, with an emphasis on applications in tissue engineering and regenerative medicine. However, his interests span from fundamental studies on biomaterial chemistry and characterization to translational research. The goals of Dr. Alge’s research group are to understand how biomaterial properties influence biological processes and to simply engineer better biomaterials. The lab specializes in hydrogels due to their diverse biomedical applications. Current projects are focused on the chemistries used to fabricate and functionalize hydrogels and the incorporation of stimulus-responsive chemical functionalities to enable tunable, dynamic changes to the material properties. These materials are being used to engineer cellular microenvironments for musculoskeletal tissue engineering, to understand the role of microenvironmental factors in infectious disease, for drug delivery, and to develop implantable biosensors. 

Selected Publications

  • C.M. Kirschner, D.L. Alge, S.T. Gould, K.S. Anseth. Clickable, photodegradable hydrogels to dynamically modulate valvular interstitial cell phenotype. Advanced Healthcare Materials, in press.
  • N.R. Gandavarapu, D.L. Alge, K.S. Anseth. a5 integrin signaling directs osteogenic differentiation in human mesenchymal stem cells on stiff substrates. Biomaterials Science, in press.
  • D.L. Alge, K.S. Anseth. Bioactive hydrogels: Lighting the way. Nature Materials, 2013; 12(11): 950-2.
  • D.L. Alge, M.A. Azagarsamy, D.F. Donohue, K.S. Anseth. Synthetically tractable click hydrogels for three-dimensional cell culture formed using tetrazine-norbornene chemistry. Biomacromolecules, 2013; 14(4): 949-53.
  • K.C. Koehler*, D.L. Alge*, K.S. Anseth, and C.N. Bowman. A Diels-Alder modulated approach to control and sustain the release of dexamethasone and induce osteogenic differentiation of human mesenchymal stem cells. Biomaterials, 2013; 34(16): 4150-8. *authors contributed equally