• Assistant Professor, Chemical Engineering

Educational Background

  • Postdoctoral Associate, Institute for Medical Engineering and Science, Massachusetts Institute of Technology - 2019
  • Visiting Postdoctoral Fellow, Wyss Institute - 2019
  • Ph.D., Chemical Engineering, University of California, Berkeley - 2017
  • B.S., Biosciences (DII), Nanjing University, China - 2012

Research Interests

  • Our research interest is biomolecular engineering for applications in health, agriculture, and energy. The research themes include discovery of biological molecules involved in microbe- and host-microbe interactions, elucidating the biosynthesis of bioactive molecules, and harnessing the knowledge to design bio-based systems for diagnostics and treatment. To advance our research, we use principles in microbiology, molecular biology, biochemistry, analytical chemistry, protein engineering, metabolic engineering, as well as emerging tools in chemical biology and synthetic biology.

Selected Publications

  • Zhu, X., Shieh, P., Su, M., Bertozzi, C. R., Zhang, W. “A fluorogenic screening platform enables directed evolution of an alkyne biosynthetic tool.” Chem. Commun. 2016, 52, 11239-11242.
  • Zhu, X., Su, M., Manickam, K., Zhang, W. "Bacterial genome mining of enzymatic tools for alkyne biosynthesis." ACS Chem. Biol. 2015, 10, 2785-2793.
  • Zhu, X., Zhang, W. "Tagging polyketides/non-ribosomal peptides with a clickable functionality and applications." Front. Chem. 2015, 3: 11.
  • Zhu, X., Liu, J., Zhang, W. “De novo biosynthesis of terminal alkyne-labeled natural products.” Nat. Chem. Biol. 2015, 11, 115-120. (selected as NCB’s greatest hit)