• Associate Professor, Chemical Engineering
Hung-Jen Wu

Educational Background

  • Ph.D., Texas A&M University
  • M.S., National Cheng Kung University, Taiwan
  • B.S., National Cheng Kung University, Taiwan

Research Interests

  • Dr. Wu uses nanostructured materials and analytical tools to develop diagnostic techniques for medical applications. His laboratory recently focuses on understanding the influences of multivalency and cell membrane environment on pathogen-host cell recognition. The applications of his techniques include, infectious diseases screening, exploring cell membrane function, and targeted drug delivery.

Awards & Honors

  • Kaneka Junior Faculty Award (2016)

Selected Publications

  • Krishnan, P., Singla, A., Lee, C.-A, Weatherston, J.D., Worstell, N.C., and Wu, H.-J.*, “Hetero-multivalent binding of Cholera Toxin Subunit B with glycolipid mixtures“, Colloids and Surfaces B: Biointerfaces, vol. 160, pp. 281-288, [Cover Article], DOI: 10.1016/j.colsurfb.2017.09.035 (2017).
  • Liu, C., Zhao, Z. , Fan, J., Lyon, C.J., Wu, H.-J., Nedelkov, D., Zelazny, A.M., Olivier, K.N., Cazares, L.H., Holland, S.M., Graviss, E.A., Hu, Y., “Quantification of circulating M. tuberculosis antigen peptides allows rapid diagnosis of active disease and treatment monitoring,” Proceedings of the National Academy of Sciences, 114 (15) 3969-3974 (2017)
  • Weatherston, J.D., Worstell, N.C., Wu, H. -J., “Quantitative Surface-Enhanced Raman Spectroscopy (SERS) for Kinetic Analysis of Aldol Condensation Using Ag-Au Core-Shell Nanocube”, Analyst, vol. 141, pp. 6051-6060 (2016). DOI: 10.1039/C6AN01098A
  • Worstell, D. N., Krishnan, P., Weatherston, D. J., Wu, H. -J., “Binding Cooperativity Matters: A GM1-like Ganglioside-Cholera Toxin B Subunit Binding Study Using a Nanocube-Based Lipid Bilayer Array,” PLOS ONE , 11(4): e0153265 (2016). DOI:10.1371/journal.pone.0153265
  • Iversen, L., Tu, H-.L., Lin, W.-C, Christensen, S.M., Abel, S.M., Iwig, J., Wu, H.-J., Gureasko, J., Yu, C-.H., Rhodes, C., Petit, R. S., Stamou, D., Chakraborty, A.K., Kuriyan, J., Groves, J.T., “Ras activation by SOS: Allosteric regulation by altered fluctuation dynamics”, vol. 345, pp.50-54, Science. (2014). DOI: 10.1126/science.1250373
  • Fan, J., Niu, S., Dong, A., Shi, J., Fine, D., Wu, H.-J., Tian, Y. et al., “Nanopore film based enrichment and quantification of low abundance hepcidin from human bodily fluids,” Nanomedicine: Nanotechnology, Biology and Medicine, vol. 10, pp. 879-888. (2014) [Cover Article].
  • Wu, H.-J., Li, Y., Fan, J., Deng, Z., Zhao, H., Graviss, E. A., Liu, X., Ferrari, M., Ma, X., Hu, Y.,“ Antibody-Free Detection of Mycobacterium tuberculosis Antigen Using Customized Nanotraps,” Analytical Chemistry, 86:1988-1996 (2014). DOI: 10.1021/ac4027669
  • Wu, H.-J., Henzie, J., Lin, W.-C., Rhodes, C., Li, Z., Thorner, J., Yang, P., Groves, J.T., "Membrane-Protein Binding Measured with Solution-Phase Plasmonic Nanocube Sensors," Nature Methods, 9:1189-91 (2012). DOI:10.1038/nmeth.2211