Phanourios Tamamis

Assistant Professor

tamamis_web

Office: 330 GERB
Phone: 979.862.1610
Email: tamamis@tamu.edu

Research Website

Research Interests

Computational methods, including molecular dynamics (MD) simulations and free energy calculations, are increasingly becoming powerful tools in the fields of protein structure prediction and de novo protein design. Despite the continuous advancement of experimental methods, computational tools have proved to be of utmost importance to fill crucial “gaps”, obtain information that is not accessible from experiments, and lead to the discovery of novel biomaterials and therapeutics.

Through the development of novel multidisciplinary computational strategies, combining biophysical-chemistry and engineering principles, our research aims at:

  1. Designing novel biomaterials with advanced applications.
  2. Elucidating the structures of key biomolecular complexes associated with amyloid diseases including diabetes, Alzheimer’s and Parkinson’s and designing novel compounds that can potentially serve as therapeutics for amyloid diseases.
  3. Understanding at an atomic level the structure of ligand : protein interactions in key biological systems such as bacteria proteins, and the discovery of novel compounds with important biomedical applications. 

For more information, please visit

http://chentamamis.wpengine.com/

 

Awards & Honors

  • The “Outstanding Young Researcher” award. Awarded by the Computational Biophysics to Systems Biology 2012 Conference, Knoxville, Tennessee, U.S.A. (2012)
  • Fulbright Grant to conduct research at the University of California at Riverside and Princeton University. (2011)
  • President of the Cyprus House of Representatives “First Prize in Physics” for the highest academic performance at the Department of Physics of the University of Cyprus, during the years 2002-2006. (2006)
  • Top Cypriot undergraduate researcher award for the academic year 2005-2006. Awarded by the Cyprus Research Promotion Foundation. (2006)

Education

  • Postdoctoral Research, Princeton University, 2013-2014
  • Postdoctoral Research, University of Cyprus, and Fulbright Postdoctoral Research, University of California at Riverside and Princeton University, 2010-2012
  • Ph.D., University of Cyprus, 2010
  • B.S., University of Cyprus, 2006

Selected Publications

Tamamis, P.; Floudas, C. A. Elucidating a Key Anti-HIV-1 and Cancer-Associated Axis: The Structure of CCL5 (Rantes) in Complex with CCR5. Scientific Reports 2014, 4, 5447.

Tamamis, P.; Floudas, C. A. Elucidating a Key Component of Cancer Metastasis: CXCL12 (SDF-1α) Binding to CXCR4. Journal of Chemical Information and Modeling 2014, 54 (4), 1174-1188.

Tamamis, P.; Floudas, C. A. Molecular Recognition of CCR5 by an HIV-1 gp120 V3 Loop. PLoS ONE 2014, 9 (4), e95767.

Tamamis, P.; Terzaki, K.; Kassinopoulos, M.; Mastrogiannis, L.; Mossou, E.; Forsyth, V. T., Mitchell, E. P.; Mitraki, A. ; Archontis, G. Self-Assembly of an Aspartate-Rich Sequence from the Adenovirus Fibre Shaft: Insights from Molecular Dynamics Simulations and Experiments. Journal of Physical Chemistry B 2014, 118 (7),1765-1774.

Gorham Jr., R. D.; Forest, D. L; Tamamis, P.; Victoria, A. L. d; Kraszni, M.; Kieslich, C. A; Banna, C. D; Bellows-Peterson, M. L; Larive, C. K; Floudas, C. A; Archontis, G.; Johnson, L. V; Morikis, D. Novel compstatin family peptides inhibit complement activation by drusen-like deposits in human retinal pigmented epithelial cell cultures. Experimental Eye Research 2013, 116, 96-108.

Tamamis, P.; Morikis, D.; Floudas, C. A.; Archontis, G. Species specificity of the complement inhibitor compstatin investigated by all-atom molecular dynamics simulations. Proteins 2010, 78 (12), 2655-2667.

Tamamis, P.; Adler-Abramovich, L.; Reches, M.; Marshall, K.; Sikorski, P.; Serpell, L.; Gazit, E.; Archontis, G. Self-Assembly of Phenylalanine Oligopeptides: Insights from Experiments and Simulations. Biophysical Journal 2009, 96 (12), 5020-5029.