What is the overall goal of your project?

The overall goal of our multidisciplinary team is to advance and validate the proof-of-concept of a novel actuating 3D printed venous valve model that was designed during the Aggie Challenge of 2017-18. The specific goals of this project are as follows:

  • Determine the fluid dynamics of an actuating venous valve.
  • Engineer a blood substitute and determine hemodynamics-dependent vein function and thrombosis.

Which grand challenge are you addressing?

  1. Engineer the tools for new scientific discovery.
  2. Engineer better medicines.

What is the key challenge your project is trying to solve?

Present animal models used in studying deep vein thrombosis (DVT) that are not predictive, they lack human physiological aspects and deep lying veins in animals are difficult to be imaged. Therefore, we will engineer a physiologically-relevant vein with venous valves in vitro to study the mechanisms of DVT and subsequently, use this model to discover and predict the performance of antithrombotic drugs.

What is the impact on society your project has?

Upon completion, we will contribute to advancing our knowledge of DVT and this device may lead to testing anticoagulants prior to giving it to the patient, thus making the treatment of DVT more efficient.

Faculty Mentor: Dr. Abhishek Jain

Targeted Engineering Majors: Biomedical Engineering, Chemical Engineering, Mechanical Engineering, Electrical Engineering