Texas A&M's Applegate to give talk on imaging technology for optical biopsy

Dr. Brian Applegate, assistant professor in the Department of Biomedical Engineering at Texas A&M University, will give a talk Monday (Sept. 20) at 4:10 p.m. in Room 106 of the Jack E. Brown Engineering Building on campus.Dr. Brian ApplegateApplegate's talk, "New High‐Resolution Optical and Molecular Imaging Technologies for Optical Biopsy," is part of the Department of Biomedical Engineering's seminar series.Abstract High‐resolution optical and molecular imaging is perhaps the best prospect to replace or at least augment tissue biopsy. In principle it provides comparable information to the histopathological evaluation of the tissue biopsy without the removal of tissue. Tissue biopsy remains the "gold standard" for the diagnosis and monitoring of numerous diseases and conditions including cancer.Unfortunately it suffers from a number of disadvantages including a lack of specificity, artifacts due to tissue preparation, the loss of dynamic molecular information because the examined tissue is dead, and patient discomfort. Moreover, many tissues cannot be easily biopsied, for instance the eye, arterial walls, and inner ear. Optical interrogation of these tissues is the only means to acquire high‐fidelity morphological and biochemical information for diagnosisWe are developing a variety of technologies aimed at noninvasive or minimally invasive imaging of tissue morphology and biochemistry, including optical coherence tomography, fluorescence lifetime imaging, and photoacoustic microscopy. Recent advances as well as the comparative advantages or each technology will be discussed.Bio Dr. Applegate received his B.S. in chemistry from Wright State University and his M.S. and Ph.D. in chemistry from The Ohio State University. His graduate work focused on the theoretical and experimental understanding of the spectroscopy and molecular dynamics of gas phase molecular radicals. He completed two postdoctoral fellowships before joining the faculty at Texas A&M. The first was in the chemistry department under Prof. Roger Miller at the University of North Carolina at Chapel Hill. The second was in the biomedical engineering department under Prof. Joseph Izatt at Duke University. The second postdoc was supported by a fellowship grant from the National Institutes of Health for the development of molecular imaging with optical coherence tomography.