Brown professor to give Lindsay Lecture talk Wednesday

Wolfgang Peti, assistant professor of medical science and chemistry at Brown University, will discuss his research Wednesday (March 3) as part of the 2010 J.D. Lindsay Lecture Series at Texas A&M University.Peti's presentation, "Structural Analysis of Dephosphorylation Machines: The Prerequisite of Flexibility," is scheduled from 3 to 4 p.m. in Rm. 106 of the Jack E. Brown Engineering Building. His presentation is sponsored by Texas A&M's Artie McFerrin Department of Chemical Engineering.The scientific focus of the Peti laboratory is to understand the molecular basis of essential biological processes.Peti says a large variety of essential cellular processes including cell cycle progression, protein synthesis, muscle contraction, carbohydrate metabolism, transcription and neuronal signaling are regulated by Protein Phosphatase 1 (PP1). However, despite its biological importance, the molecular basis for the ability of regulatory proteins to direct the specificity of PP1 is not understood, he notes.Peti's presentation will provide what he says is the first molecular insight into the interaction of PP1 with multiple essential PP1 regulatory protein, including spinophilin, the most important neuronal PP1 targeting protein that regulates AMPA receptor trafficking among other critical biological functions, as well as other essential targeting proteins and inhibitors.The Manning Assistant Professor of Medical Science at Brown University, Peti earned his undergraduate degree from the University of Vienna, Austria and his Ph.D from the University of Frankfurt, Germany in 2001. Among his honors, Peti has received the Ernst Award of the German Chemical Society and the Richard B. Salomon Faculty Research Award.In honor of Professor J.D. Lindsay, Texas A&M's first chemical engineering department head, the department established the Lindsay Lecture Series to bring speakers to the university. Coming from both industry and academia, the lecturers are recognized for their accomplishments in the practice, teaching and/or research of chemical engineering. The series also allows the lecturers several days for visiting the university and the department and for exchanging ideas on teaching and research objectives and methods.Written by Ryan Garcia,