Hung-Jen Wu

Assistant Professor

Wu_2015_web

Office: 227 CHEN
Phone: 979.862.1454
Fax: (979) 845-6446
Email: hjwu@tamu.edu

Research Website

Research Interests

Dr. Wu uses nanostructured materials and analytical tools to develop diagnostic techniques for medical applications. His laboratory recently focuses on understanding the influences of multivalency and cell membrane environment on pathogen-host cell recognition. The applications of his techniques include, infectious diseases screening, exploring cell membrane function, and targeted drug delivery.

Awards & Honors

  • Kaneka Junior Faculty Award (2016)

Education

  • B.S., National Cheng Kung University, Taiwan
  • M.S., National Cheng Kung University, Taiwan
  • Ph.D., Texas A&M University

Selected Publications

Krishnan, P., Singla, A., Lee, C.-A, Weatherston, J.D., Worstell, N.C., and Wu, H.-J.*, “Hetero-multivalent binding of Cholera Toxin Subunit B with glycolipid mixtures“, Colloids and Surfaces B: Biointerfaces, vol. 160, pp. 281-288, [Cover Article], DOI: 10.1016/j.colsurfb.2017.09.035 (2017).

Liu, C., Zhao, Z. , Fan, J., Lyon, C.J., Wu, H.-J., Nedelkov, D., Zelazny, A.M., Olivier, K.N., Cazares, L.H., Holland, S.M., Graviss, E.A., Hu, Y., “Quantification of circulating M. tuberculosis antigen peptides allows rapid diagnosis of active disease and treatment monitoring,” Proceedings of the National Academy of Sciences, 114 (15) 3969-3974 (2017)

Weatherston, J.D., Worstell, N.C., Wu, H. -J., “Quantitative Surface-Enhanced Raman Spectroscopy (SERS) for Kinetic Analysis of Aldol Condensation Using Ag-Au Core-Shell Nanocube”, Analyst, vol. 141, pp. 6051-6060 (2016). DOI: 10.1039/C6AN01098A

Worstell, D. N., Krishnan, P., Weatherston, D. J., Wu, H. -J., “Binding Cooperativity Matters: A GM1-like Ganglioside-Cholera Toxin B Subunit Binding Study Using a Nanocube-Based Lipid Bilayer Array,” PLOS ONE , 11(4): e0153265 (2016). DOI:10.1371/journal.pone.0153265

Iversen, L., Tu, H-.L., Lin, W.-C, Christensen, S.M., Abel, S.M., Iwig, J., Wu, H.-J., Gureasko, J., Yu, C-.H., Rhodes, C., Petit, R. S., Stamou, D., Chakraborty, A.K., Kuriyan, J., Groves, J.T., “Ras activation by SOS: Allosteric regulation by altered fluctuation dynamics”, vol. 345, pp.50-54, Science. (2014). DOI: 10.1126/science.1250373

Fan, J., Niu, S., Dong, A., Shi, J., Fine, D., Wu, H.-J., Tian, Y. et al., “Nanopore film based enrichment and quantification of low abundance hepcidin from human bodily fluids,” Nanomedicine: Nanotechnology, Biology and Medicine, vol. 10, pp. 879-888. (2014) [Cover Article].

Wu, H.-J., Li, Y., Fan, J., Deng, Z., Zhao, H., Graviss, E. A., Liu, X., Ferrari, M., Ma, X., Hu, Y.,“ Antibody-Free Detection of Mycobacterium tuberculosis Antigen Using Customized Nanotraps,” Analytical Chemistry, 86:1988-1996 (2014). DOI: 10.1021/ac4027669

Wu, H.-J., Henzie, J., Lin, W.-C., Rhodes, C., Li, Z., Thorner, J., Yang, P., Groves, J.T., "Membrane-Protein Binding Measured with Solution-Phase Plasmonic Nanocube Sensors," Nature Methods, 9:1189-91 (2012). DOI:10.1038/nmeth.2211