Dr. Wu’s research focuses on using nanostructured materials and analytical tools to develop diagnostic techniques for disease screening. The applications of these techniques include, infectious diseases screening (e.g. tuberculosis, HIV, etc), imaging complex biological networks that are critical to the development of diseases (e.g. cancer), exploring cell membrane function, and drug discovery.
- B.S., National Cheng Kung University, Taiwan
- M.S., National Cheng Kung University, Taiwan
- Ph.D., Texas A&M University
Iversen, L., Tu, H-.L., Lin, W.-C, Christensen, S.M., Abel, S.M., Iwig, J., Wu, H.-J., Gureasko, J., Yu, C-.H., Rhodes, C., Petit, R. S., Stamou, D., Chakraborty, A.K., Kuriyan, J., Groves, J.T., “Ras activation by SOS: Allosteric regulation by altered fluctuation dynamics”, vol. 345, pp.50-54, Science. (2014).
Fan, J., Niu, S., Dong, A., Shi, J., Fine, D., Wu, H.-J., Tian, Y. et al., “Nanopore film based enrichment and quantification of low abundance hepcidin from human bodily fluids,” Nanomedicine: Nanotechnology, Biology and Medicine, vol. 10, pp. 879-888. (2014). Reported by Science Translational Medicine (Editors' Choice), vol. 6, Issue 227, p. 227ec44 (2014), DOI: 10.1126/scitranslmed.3008861
Wu, H.-J., Li, Y., Fan, J., Deng, Z., Zhao, H., Graviss, E. A., Liu, X., Ferrari, M., Ma, X., Hu, Y.,“ Antibody-Free Detection of Mycobacterium tuberculosis Antigen Using Customized Nanotraps,” Analytical Chemistry, 86:1988-1996. (2014) Highlighted in Chemical & Engineering News, 2014; http://cen.acs.org/articles/92/web/2014/02/Diagnosing-Tuberculosis-Nanotrap.html
Wang, Z., Fine, D., Wu, H.-J., Schmulen, J., Hu, Y., Godin, B., Zhang, J.X., Liu, X., “Ciliated micropillars for the microfluidic-based isolation of nanoscale lipid vesicles,” Lab-on-a-chip, 13:2879-2882. (2013).
Fan, J., Huang, Y., Finoulst, I., Wu, H.-J., Deng, Z., Xu, R., Ferrari, R., Shen, H., Hu, Y., “Low Molecular Weight Serum Biomarkers for Pulmonary Metastatic Melanoma Identified by means of a Nanopore-based Assay,” Cancer Letter, 334: 202-10 (2013).
Wu, H.-J., Henzie, J., Lin, W.-C., Rhodes, C., Li, Z., Thorner, J., Yang, P., Groves, J.T., "Membrane-Protein Binding Measured with Solution-Phase Plasmonic Nanocube Sensors," Nature Methods, 9:1189-91 (2012).
Yu, Y., Fay, N.C., Smoligovets, A., Wu, H.-J., Groves, J.T., "Myosin IIA modulates T cell receptor transport and casl phosphorylation during early immunological synapse formation," PloS ONE, 7:e30704 (2012).