My research focus on harnessing the unique characteristics of transport and flow at the microscale to enable new chemical and biochemical analysis technologies. Specific areas of interest include:
• Learning how to control transport of charged biomolecules (DNA, proteins) in micro- and nano-scale surroundings to achieve faster and more efficient separations
• Harnessing microscale convective flow fields to execute thermally driven biochemical reactions such as the polymerase chain reaction (PCR) in a faster and more efficient manner
• Designing novel geometries to mix chemical species in microchannels by exploiting secondary flow phenomena
• Developing new techniques that help understand how to manipulate and tailor the bulk properties of hydrogels by controlling their nanoporous morphology
• Constructing 3D vascular networks for biomedical applications using novel manufacturing methods
Awards & Honors
- Charles Crawford Distinguished Service Award
- Ph.D., Northwestern University, 1999
- M.S., University of Texas at Austin, 1994
- B.S., University of Texas at Austin, 1991
Shi, N. and Ugaz, V.M. “An Entropic Force Microscope Enables Nano-scale Conformational Probing of Biomolecules.” Small, 10 (2014): 2553-2557.
Meng, F., King, M.D., Hassan, Y.A., and Ugaz, V.M. “Localized Fluorescent Complexation Enables Rapid Monitoring of Airborne Nanoparticles.” Environmental Science: Nano, 1 (2014): 358-366.
Priye, A., Hassan, Y.A., and Ugaz, V.M. “Microscale Chaotic Advection Enables Robust Convective DNA Replication.” Analytical Chemistry, 85 (2013): 10536-10541.
Contreras-Naranjo, J.C. and Ugaz, V.M. “A Nanometer-scale Resolution Interference-based Probe of Interfacial Phenomena Between Microscopic Objects and Surfaces.” Nature Communications, 4 (2013): DOI:10.1038/ncomms2865.
Huang, J-H., Jayaraman, A., and Ugaz, V.M. “Enzymatic Sculpting of Nano- and Micro-scale Surface Topographies.” Angewandte Chemie International Edition, 51 (2012): 9619-9623.
Huang, Y-W., Shaikh, F.A., and Ugaz, V.M. “Tunable Synthesis of Encapsulated Microbubbles by Coupled Electrophoretic Stabilization and Electrochemical Inflation.” Angewandte Chemie International Edition, 50 (2011): 3739-3743.
Muddu, R., Hassan, Y.A., and Ugaz, V.M. “Chaotically Accelerated PCR by Microscale Rayleigh-Bénard Convection.” Angewandte Chemie International Edition, 50 (2011): 3048-3052.
Shi, N. and Ugaz, V.M. “Tailoring the Nanoporous Architecture of Hydrogels to Exploit Entropic Trapping.” Physical Review Letters, 105 (2010): 108101.
Ozturk, S., Hassan, Y.A., and Ugaz, V.M. “Interfacial Complexation Explains Anomalous Diffusion in Nanofluids.” Nano Letters, 10 (2010): 665-671.
Huang, J-H., Kim, J., Agrawal, N., Sudarsan, A.P., Maxim, J.E., Jayaraman, A., and Ugaz, V.M. “Rapid Fabrication of Bio-inspired 3-D Microvascular Networks.” Advanced Materials, 21 (2009): 3567-3571. Cover Article (Issue 35).
Chen, X. and Ugaz, V.M."Investigating DNA Migration in Pulsed Fields Using a Miniaturized Field Inversion Gel Electrophoresis System." Electrophoresis, 29 (2008): Accepted for publication.
Lo, R.C. and Ugaz, V.M."Microchip DNA Electrophoresis with Automated Whole-Gel Scanning Detection." Lab on a Chip, 8 (2008):Accepted for publication (DOI: 10.1039/B811033F).
Wang, J., Gonzalez, A.D., and Ugaz, V.M."Tailoring Bulk Transport in Hydrogels Through Control of Polydispersity in the Nanoscale Pore Size Distribution." Advanced Materials, 20 (2008): In press (DOI: 10.1002/adma.200801303).
Agrawal, N. Hassan, Y.A., and Ugaz, V.M."A Pocket-sized Convective PCR Thermocycler."Angewandte Chemie International Edition, 46 (2007): 4316-4319.Designated as a "Very Important Paper" by the journal editors.Highlighted in New Scientist [Iss. 2602 (5 May, 2007): 27].
Sudarsan, A.P. and Ugaz, V.M. “Multivortex Micromixing.” PNAS, 103 (2006): 7228-7233.
Shaikh, F.A. and Ugaz, V.M. “Collection, Focusing, and Metering of DNA in Microchannels Using Addressable Electrode Arrays for Portable Low-power Bioanalysis.” PNAS, 103 (2006): 4825-4830.